Cannabiglendol C3 molecule

What is Cannabiglendol-C3?

Cannabiglendol-C3 is one of the earliest forms of cannabinoids discovered in the cannabis plant. Although the compound was reported by Turner et al in 1981, there is still little to no information concerning its therapeutic benefits and possible interaction with other cannabinoids. Cannabiglendol-C3 was isolated from the leaves and small stems of an Indian variant of Cannabis Sativa grown in Mississippi.

As a derivative of cannabinol with IUPAC name as 8-OH-sisohexaliydrocannabinol, Cannabiglendol is considered as a hydroxyl-derivative of the cannabinol group of cananbinoids. Since cannabiglendol-C3 share some similarities with cannabinol (CBN), the compounds may share similarities in their interaction with the cannabinoid receptors and possible therapeutic benefits.

Cananbinol (CBN) is a mildly psychoactive member of the cannabinoid family and occurs in trace amounts in cannabis plant. It is highly concentrated in aged cannabis plant and are also formed as a metabolite of tetrahydrocannabinol (THC). Although cannabinol have been successfully extracted in trace quantities in the cannabis plant, there are debates on whether it should be regarded as a naturally occurring or synthetic cannabinoid.

At the time of writing this report, we are quite unsure of the connection between CBN and cannabiglendol-C3 other the possession of the same parent chain from where cannabiglendol-3 is a hydroxyl derivative.

How does Cannabiglendol C3 work?

As stated earlier, cannabiglendol-C3 is an uncategorized (miscellaneous) cannabinoid. Information concerning its interaction with the cannabinoid receptors is still unknown. Since it has some relationship with CBN, it is believed that cannabiglendol may be slightly psychoactive or may exhibit a completely different interaction with the cannabinoid receptors once tested. Since the compound in present in minute quantities, carrying out a detailed research to understand its level of activity and therapeutic benefits may be regarded as a waste of valuable resources.

It is pertinent to also note that cannabiglendol was only isolate from the leaves and stems of Indian Variants of cannabis sativa grown in Mississippi. There are little to no pieces of information of its presence in other cannabis plants around the world. For now, we are optimistic scientist may pick interest in the cannabinoid and carry out a detailed research on its activity and potential therapeutic benefits.

Potential Therapeutic Benefits

There is little to no information about the potential benefits of Cannabiglendol in treating diseases or providing therapeutic benefits to animals. Since the compound shares some characteristics with CBN, it is possible the two compounds may exhibit a similar interaction with the cannabinoid receptors.

Interesting Facts

  1. Cannabiglendol-C3 has a molecular weight of 304.42g/mol
  2. It is often regarded as a hydroxyl cannabinoid
  3. It was extracted from the stems and leaves of Indian variants of cannabis sativa plants grown in Mississippi.
  4. It shares some structural similarities with the mildly psychoactive Cannabinol (CBN).
  5. Cannabiglendol-C3 is also known as 8-OH-sisohexaliydrocannabinol


Turner, C. E., Mole, M. L., Hanus, L., & Elsohly, H. N. (1981). Constituents of Cannabis sativa. XIX. Isolation and Structure Elucidation of Cannabiglendol, A Novel Cannabinoid From an Indian Variant. Journal of Natural Products, 44(1), 27–33. 

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