CANNABICHROMEVARIN (CBCV)

 

What is Cannabichromevarin?

Cannabichromevarin (CBCV), also referred to as cannabivarichromene is one of the more than 120 types of cannabinoid chemical compounds found in the cannabis plant. It also acts on cannabinoid receptors. CBCV is a phytocannabinoid found naturally in the cannabis plant; it is also a propyl cannabinoid, making it an effective anticonvulsant.

Cannabichromevarin (CBCV) was first identified in 1975 at the University of Nagasaki in a marijuana strain obtained from Thailand. CBCV can only be found in small amounts in marijuana plants, hence its lack of proper research. The closest related cannabinoid to CBCV is the CBC (cannabichromene). They have similar small chemical structure. 

At first, cannabichromevarinic acid (CBCVA) is produced by marijuana. Once exposed to heat, it loses the acid transforming it into a neutral cannabinoid rather than acidic. The process whereby the A – acid is removed is known as decarboxylation.

CBCV, just like other cannabinoids, has great medical benefits. This is being hindered by the lack of adequate research that will fully understand what it’s capability. As a result of the law changes that govern the use of cannabis in most nations, people are starting to see the benefit of this plant; we might soon discover more about what CBCV has to offer.

HOW DOES IT WORK?

No matter how you decide to consume cannabis, it will have the same effect on you. This is because of how the chemical interacts with the endocannabinoid system (ECS) of the body. Every cannabinoid, including CBCV, interacts with the body in this similar way. ECS receptors are basically in every part of the body; eyes, brain, immune system, etc. There is still ongoing research concerning the ECS to know how many receptors we have and better understand how they work.

POSSIBLE THERAPEUTIC BENEFITS 

The lack of studies for CBCV makes us assume based on what we know about CBG. It is used to treat the following;

1. Glaucoma

According to a study done in 2008, it is said that the presence of endocannabinoid receptors in the eyes contributes to the control of Intraocular Pressure (IOP) – the formation and outflow of aqueous humor. Also, there is ongoing research that claims this process helps in the eradication of retinal ganglion cells, which causes glaucoma.

2. Inflammatory Bowel Disease

In a study done on mice in 2013, CBG is said to eradicate murine colitis, reduce nitric acid production in the macrophages, and reduce the formation of ROS in intestinal epithelial cells. Researchers are confident CBG can be used to treat patients with inflammatory bowel disease. 

3. Colon Cancer

There are reports that CBG inhibits the growth of Colorectal Cancer Cells (CRC). It is also reported that CBG inhibits the growth of colon carcinogenesis that are induced chemically. This process contains the progression of colon cancer. 

INTERESTING FACTS

  1. Even though CBCV is deemed safe for consumption, gravid and breastfeeding women are warned against its use as there is no research yet on this.
  2. High doses of cannabinoid are said to have worsened the symptoms of those with Parkinson’s disease.

REFERENCES

  1. ‌Nadolska K, Goś R. Mozliwości zastosowania kannabinoidów w leczeniu jaskry [Possibilities of applying cannabinoids’ in the treatment of glaucoma]. Klin Oczna. 2008;110(7-9):314-317.
  2. ‌Borrelli F, Fasolino I, Romano B, et al. Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease. Biochem Pharmacol. 2013;85(9):1306-1316. doi:10.1016/j.bcp.2013.01.017
  3. ‌Borrelli F, Pagano E, Romano B, et al. Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid. Carcinogenesis. 2014;35(12):2787-2797. doi:10.1093/carcin/bgu205

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