CANNABIGEROVARINIC ACID (CBGVA)

WHAT IS CANNABIGEROVARINIC ACID (CBGVA)?

Beyond doubts, there are two most popular cannabinoids; Tetrahydrocannabinol – THC and Cannabidiol CBD of the plant cannabis while each of them has its specific benefits. However, the cannabis plant does not make these cannabinoids directly. Rather, cannabinoids acids like CBGVA are synthesized, these are then decarboxylated to create the popular CBD and THC that we know. CBGVA is a type of acid that creates a smaller molecule once the A – acid has been decarboxylated. CBGVA is what we call ‘precursor cannabinoids’.

Since CBGVA is a precursor cannabinoid of CBGV, and CBGV is gotten from CBG, we can then say the same process begat them all. In the year 1964, CBG was first discovered in Israel by researchers Yehiel Gaoni and Raphael Mechoulam. These two Marijuana researchers were able to isolate CBG, THC, and CBD from the cannabis plant. They may at that time have not been able to see how important this is, but we can say their research found the basis for other cannabinoids. 

CBGVA as stated earlier is another building block for cannabinoids. It is a naturally occurring parent cannabinoid just like CBGA. Any cannabinoid that has “V” in its name means it contains divarinolic acid, which causes them to have fewer carbon atoms than the rest of the cannabinoids without “V”. 

So far, there is very little information available about CBGVA. The ongoing debate about the acceptance of cannabis across the world is limiting research and studies done in regards to the compounds found in the plat.

HOW DOES IT WORK

Since CBGVA is also one of the produced acids of CBD thus we can say that it might possess a similar working mechanism as that of CBG. Just like every other cannabinoid, CBG functions by impacting the Endocannabinoid System (ECS) within our body. These endocannabinoids are compounds produced by our body, they are responsible for things like mood and appetite. The major function is to ensure the regulation of physiological functions and maintenance of internal balance.   

POSSIBLE THERAPEUTIC BENEFITS

The medical benefits of CBGVA are yet to be known, but hopefully would be known in the future. But since CBGVA is also one of the produced acids of CBD, we can then say that it might possess similar therapeutic benefits as that of CBG.

  1. Eyecare

Although the research has only been done on lab animals, there are reports that CBG can play an active position in the treatment of glaucoma. Researchers are then sure that this CBG might produce similar benefits when applied to humans.

  1. Anti-bacterial properties

There are scientific reports that say CBG has good anti-bacterial properties, especially against drug-resistant MRSA. Biofilms are communities of microorganisms that cause resistance to the power of antibiotics, research shows that CBG helps to prevent the formation of these biofilms.

  1. Pain relief

A study done in 2010 shows that CBG can serve as an analgesic, even better than THC. The study done on rats shows that CBG can act as an alpha-2-adrenoreceptor agonist, which means it can control the sensation of pain in rats.

INTERESTING FACTS

  • CBGVA is another building block for cannabinoids. It is also a naturally occurring ‘parent cannabinoid’ like CBGA. 
  • Just like CBGA, CBGVA is another precursor cannabinoid. CBGVA produces CBGV through the process of decarboxylation.

REFERENCES

  • COLASANTI, B. K. (1990). A Comparison of the Ocular and Central Effects of Δ9-Tetrahydrocannabinol and Cannabigerol. Journal of Ocular Pharmacology and Therapeutics, 6(4), 259–269. DOI: https://doi.org/10.1089/jop.1990.6.259 
  • Maya A. Farha, Omar M. El-Halfway, Robert T. Gale, Craig R. MacNair, Lindsey A. Carfrae, Xiong Zhang, Nicholas G. Jentsch, Jakob Magolan, Eric D. Brown. Uncovering the Hidden Antibiotic Potential of Cannabis. ACS Infectious Diseases, 2020; DOI: 10.1021/acsinfecdis.9b00419
  • Banerjee SP, Snyder SH, Mechoulam R. Cannabinoids: influence on neurotransmitter uptake in rat brain synaptosomes. J Pharmacol Exp Ther. 1975;194(1):74-81

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