CANNABIGEROVARIN (CBGV)

WHAT IS CANNABIGEROVARIN (CBGV)?

The benefit of cannabis to the human body is far beyond just enjoying a night out with friends by the lakeside while enjoying some munchies. Cannabinoids like THC and CBD are the most popular when we talk about this plant’s compound. Another cannabinoid is cannabigerovarin, also known as CBGV. CBGV is a cannabinoid acid that is a derivative of CBG – “the mother of all cannabinoids”. Both THC and CBD also originate from CBG, and without it, the potential of cannabis won’t be as wide as it is today. Just like other cannabinoids, CBGV does not produce any psychoactive effects, unlike THC – which does.

CBG the mother of all cannabinoids was discovered by Yehiel Gaoni and Raphael Mechoulam in the year 1964 as a non-psychoactive member of the cannabinoid family. The compound was isolated by the researchers from Hashish, a resin that was developed from an active flowering marijuana plant.

CBGV is derived from CBG, and just like other cannabinoid, the acid is activated once it is exposed to light or heat. Cannabis contains certain elements in which CBGV and other acids are part of. These elements function in protecting the plants from insecticide infections and building resistance to diseases. As stated earlier, CBGV gets activated once heated. This process is known as the decarboxylation process. The application of heat and light can convert CBGV to CBD. There are even suggestions that the relationship between CBGV and CBD is similar to that of THCV and THC.

There is little known about CBGV, and available research works are severely limited. That being said, with the amount of study going on concerning the cannabis plant, there are good indicators that cannabinoids have medical potentials in treating ailments and boosting the overall human body condition.

HOW DOES CBGV WORK?

The most evident feature of CBGV is its interaction with the CB1 receptors of the peripheral and central nervous systems. The effects get more interesting as CBGV helps in the metabolism of CBD. It can also help dampen the effect of THC on cell receptors. CBGV is seen as a stimulator for other cannabis cannabinoids for them to better fuse to the Endocannabinoid System (ECS) receptors.

POSSIBLE THERAPEUTIC EFFECTS

Looking at the way CBGV works in the body, we can say it supports the effects of other cannabinoids by boosting them. This implies that CBGV has medicinal benefits.

  1. Skin disease

While other cannabinoids are known for their anti-inflammatory benefit, CBGV according to a procedure carried out through non-psychotropic medication is said to be able to treat acne. 

  1. Eye diseases

CBG is known for its effects in draining aqueous fluid in the eye. Used in combination with CBGV helps in relieving painful intraocular pressure. This is made possible because of the anti-inflammatory and antibacterial methods of action that CBGV and CBG share. 

  1. For treating cancer

A study carried out at the University of St. George’s London on the use of non-psychoactive for the treatment of cancer. It was reported that the combination of CBG and CBGV showed shrinkage in cancerous cells and prevented the development of metastases. CBGV caused a halt in all phases of the cell cycle.

INTERESTING FACTS

  • The application of heat and light can convert CBGV to CBD. 
  • There are even suggestions that the relationship between CBGV and CBD is similar to that of THCV and THC. 

REFERENCES

Oláh A, Markovics A, Szabó-Papp J, et al. Differential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrhoeic skin and acne treatmentExp Dermatol. 2016;25(9):701-707. doi:10.1111/exd.13042

Nadolska K, Goś R. Mozliwości zastosowania kannabinoidów w leczeniu jaskry [Possibilities of applying cannabinoids’ in the treatment of glaucoma]. Klin Oczna. 2008;110(7-9):314-317.

Katherine Ann Scott, Sini Shah, Angus George Dalgleish And Wai Man Liu. Enhancing the Activity of Cannabidiol and Other Cannabinoids In Vitro Through Modifications to Drug Combinations and Treatment SchedulesAnticancer Research, October 2013

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