CANNABIDIOL MONOMETHYLETHER (CBDM)

WHAT IS CANNABIDIOL MONOETHYLETHER (CBDM)?

Cannabidiol monomethylether (CBDM) is one of the components of Marijuana or cannabis plant. The Cannabis plant is a plant belonging to the family of Cannabaceae having only one genus which is Cannabis and a specie which can be highly variable. Over the years, especially in the mid-seventies, the quest for the existence of new natural cannabinoids that were as a result of isolation from the Cannabis sativa preparation with other sub-species and varieties gave birth to the discovery of Cannabidiol (CBD) alongside  (–)- trans-Δ –tetrahydrocannabinol (Δ –THC) as the most abundant components of the Cannabis plant. These two have been subsequently considered as the most relevant curative components of the plant thereby making Cannabidiol Monomethylether (CBDM) a promising curative component too. Studies, however has revealed that it might be difficult to classify cannabidiol monomethylether as either a natural or synthetic cannabidnoidic derivative of Cannabidiol (CBD). Nonetheless, evidences are that the compound must have existed in natural form. Moreover worthy of note is the fact CBDM exists in minute quantities in the cannabis plant thus making it impossible for the compound to be isolated in the first attempt.

Considering the present studies and after multiple examinations, it is concluded that Cannabidiol Monomethylether (CBDM) is a natural component of the cannabis plant. There have been some tests to isolate the Cannabidiol Monomethyl Ether (CBDM) as the new minor cannabinoid by using or from the ‘Minamioshihara No. 1’ – domestic hemp.

Since Cannabidiol monomethylether (CBDM) is a derivative of Cannabidiol (CBD) and just little is known about it, much clues about the compound is linked to the properties of Cannabidiol (CBD). Cannabidiol was isolated in 1940 (Adams et al., 1940) and its absolute configuration established by synthesis of ()-CBD as ()-trans-(1R,6R)(Petrzilka et al., 1969). The optical rotation of cannabidivarin was reported as [a]D 139.5(chloroform) (Vollner et al., 1969). All of the known CBD-type cannabinoids have trans-(1R,6R) absolute configuration and presumably also negative optical rotation.

HOW IT WORKS

Oxidative metabolism of cannabidiol monomethyl ether (CBDM), one of the components of marijuana, was studied in the guinea pig and Cannabielsoin monomethyl ether (CBEM) was found to be formed with hepatic microsomes by gas chromatography-mass spectrometry (GC-MS). Experiments using various modifiers of enzymatic reaction suggested that, as in the case of cannabielsoin (CBE) formation from canabidiol (CBD), CBEM was formed from CBDM by the monooxygenase system including cytochrome P450. When cannabidiol dimethyl ether (CBDD), in which phenolic hydroxyl groups of CBD are masked with methyl groups, was incubated with liver microsomes and a reduced nicotinamide adenine dinucleotide phosphate-generating system, 1S, 2R-epoxy-CBDD was identified by GC-MS .

THERAPEUTIC BENEFITS

To every cannabinoid, there is always a unique pharmacological effect and to this, CBDM is not an exception. As a derivative of Cannabidiol, it can also serve, among many others, as:

  • An anti-epileptic medicine. 
  • Cannabidiol monomethylether has tendencies to prevent and serve as a cure for epilepsy though further research is ongoing concerning this.
  • An anti-inflammatory remedy.
  • Cannabidiol monomethylether just like many other cannabinoids can work effectively to reduce inflammation/swelling.
  • An aid to mobilization, cannabidiol monomethylether has a medical benefit of aiding movement. This implies it has the capacity of interacting with bones and every hormone responsible for movement to bring about the best result.

INTERESTING FACTS

Cannabidiol monomethylether can serve as a curative for memory-related issues.

REFERENCES

Adams, R., Hunt, M., Clark, J.H., 1940. Structure of cannabidiol, a product isolated from the marihuana extract of Minnesota wild hemp. I. Journal of the American Chemical Society 62, 196–200.

Petrzilka, T., Haefliger, W., Sikemeier, C., 1969. Synthesis of hashish components. IV. Helvetica Chimica Acta 52 (4), 1102–1134.

Vollner, L., Bieniek, D., Korte, F., 1969. Hashish. Cannabidivarin, a new hashish component. Tetrahedron Letters 3, 145–147.

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